Inulin as a possible new tactic for weight loss

Researchers looking at novel ways to try to reduce obesity have stumbled upon inulin.  More on that in a moment.

Obesity in the US has been increasing for years. As of 2010, more than one-third of US adults (34.9%) are obese.

Obesity-related conditions include things like heart disease, stroke and type 2 diabetes, among others. Some are leading causes of preventable death (meaning, it’s a risk you can do something about). Medical care related to obesity costs almost $150 billion/year.

Dieting and exercise can cause weight loss, but many people can’t seem to follow a plan that involves changing eating habits for any length of time. Others stop, or never start, regular exercise. Some try medications, fasts, cleanses, purging. Weight-loss surgery is another option. Others may try illegal drugs. Often, these methods don’t work for a large number of people. Investigators have been looking for ways to enhance weight loss for decades.

These researchers may have come across a method that will allow safe weight loss through a form of appetite suppression using, not a drug, but carbohydrates. And not just any carbohydrates, but fermentable carbohydrates.

inulinThe researchers used mice in their experiments. They fed the mice high-fat diets. One group were given a high-fat diet supplemented with cellulose. Cellulose is a poorly-fermentable carbohydrate found in plant cell walls (“fiber”). The other mice were also given a high-fat diet, and the carbohydrate that they were given was inulin (found in a number of different plants like wheat, chicory and several others). Inulin is fermentable. The bacteria in the gut can use inulin to ale different compounds. Some of the compounds made from inulin were short-chain fatty acid acetate. The mice fed the inulin-containing diet ate less food and gained less weight than the mice fed cellulose.

Next the experimenters wanted to see if acetate alone, injected into the mice would produce the same results. It did.

To see what was happening biochemically, they scanned mouse brains after the mice were injected with radioactive acetate (acetate is a chemical that is normally made in the body). Some of the acetate concentrated in the hypothalamus of the brain, in a specific area called the arcuate nucleus. Some of the radioactive carbon from the labeled acetate was found in some neurotransmitters and small neuropeptides (small protein-like molecules) in the same area of the brain.

The investigators think that the acetate (or byproducts of the acetate) in the brain acts as a kind of anorexic chemical. That is, it somehow signals the brain that the animal no longer needs to eat, temporarily. Therefore less food gets consumed and less weight is gained.

This is an interesting approach, using compounds normally found in some foods to help control appetite, rather than using a drug that is synthesized from chemicals.

There is still a lot of research that needs to be done to see if this also happens in humans, if it’s safe to use in humans, how much inulin needs to be consumed, etc. If that future research shows that it does work, inulin or acetate might be a useful adjunct to help with weight loss.

But for now, it’s still good advice to stick to diet and exercise.  (Read more about this study here.)

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Mark Thoma, MD, is a physician who did his residency in internal medicine. Mark has a long history of social activism, and was an early technogeek, and science junkie, after evolving through his nerd phase. Favorite quote: “The most exciting phrase to hear in science... is not 'Eureka!' (I found it!) but 'That's funny.'” - Isaac Asimov

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83 Responses to “Inulin as a possible new tactic for weight loss”

  1. cmine680 says:

    I’m dieting ante and have 100 pounds to lose in total, but obviously not going to lose everything in 12 weeks. I’ll take what I can get. Once until 12 weeks should be enough to lose weight in order to get properly start a new exercise plan. Keeps things interesting for me.

    1 full week and lost 8 pounds.

    Slendera Garcinia Cambogia

  2. Drew2u says:

    Dr Thoma, what do you think of South Dakota’s Initiated Measure 17? I can’t find anything but the “Yes on 17” site. Is there a way of properly scrutinizing initiatives like this?

  3. will says:

    As part of a lawsuit against doctors taking Big Pharma kickbacks to push drugs onto their patients, a number of companies were forced to publish the amounts of money.

  4. will says:

    Here you go Mr. Thoma, knock yourself out:

    Kiehm TG, Anderson JW, Ward K.. Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men. Am J Clin Nutr. 1976 Aug;29(8):895-9.

    Singh I. Low-fat diet and therapeutic doses of insulin in diabetes mellitus. Lancet. 1955 Feb 26;268(6861):422-5.

    Barnard RJ, Lattimore L, Holly RG, Cherny S, Pritikin N.Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise. Diabetes Care. 1982 Jul-Aug;5(4):370-4.

  5. will says:

    okay, that makes sense, congrats on a job well done, who knew you had it in you.

  6. will says:

    Mr. Thoma, you shouldn’t really try funny, you’re not very good at it. Lacks any sort of originality.

  7. will says:

    It depends. Doctors are not infallible Mr. Thoma. Neither are electricians or lawyers. I am the one responsible for my health and I am going to make my own choices thank you very much. I went to the doctor for a diagnosis for vision issues. He discovered I was diabetic and wanted to get me on the Pharma track. I rejected that path. Calling that behavior suspicious is just plain arrogant.

  8. will says:

    Yeah, I didn’t think you would be impressed that has not been rubber stamped by the medical industrial complex that you participate in. Also – this is a comments section, not a courtroom.

  9. a1 says:

    Yes, and after looking at that table, I don’t know how they can call the diet a “high fat diet” when there is 50% more sugar than fat on a gram/kg basis.

  10. docsterx says:

    Recent research (NOT done on animals) showed that people who were more successful at making positive life changes (like losing weight, quitting smoking, exercising, etc.) showed that the ones who were more successful had an attitude that was different from those who had difficulty in making those same changes. The more successful group believed that they COULD change (that life was a process of growth, development and change.) The group that did less well had the belief summed up by the “you can;t teach an old dog new tricks” adage. The latter group seemed to feel that they were almost predestined to fail.

    Follow up studies now being done to see if the “old dogs” can make positive changes if thay have an attitude adjustment.

  11. docsterx says:

    There have been a number of studies done on rats that were exercised for varying amoounts of time, at different intensities of exercise. They showed that – uh, never mind. That was animal research and that doesn’t count. The ARD (Animal Research Denier) will be along in a few hours to post his rebuttal. You know that study sponsored by Good Housekeeping and People Eating Tasty Animals that says that the rats were mutants who were hung over and hadn’t given informed consent to be in the study? So it doesn’t apply to humans. But big pharma will be making an exercise pill to sell and the researchers have all made billions off of the tiny rat exercycles that they designed and sold from the experiment.

  12. docsterx says:

    There have been a few recent studies that essentially shows that walking has several benefits from some weight loss, to improved cardiovascular health, to decreased stress and others. It used to be thought that only specified blocks of aerobic exercise helped. They definitely do, but just about any exercise is beneficial. Provided that the person who started exercising doesn’t increase his food intake.

  13. docsterx says:

    I’m always suspicious of a patient who goes to a doctor to get the physician’s professional opinion and then totally rejects it out of hand to instead self-treat. Would this person also reject the advice of his financial adviser, electrician, lawyer? If he’s already so knowledgeable, just skip the whole business and file the lawsuit, rewire the house and invest in Enron himself.

  14. docsterx says:

    Please reread my comments, made more than once concerning the “evidence” that you cite. I mentioned that to have a debate on information gathered from scientific research you need to cite studies, reports or other communications that have been presented in established journals. And those papers need to be peer-reviewed. Time, NPR, the Huffington Post and the others that you mentioned don’t meet those criteria.

  15. docsterx says:

    Not true.
    I try to not be biased and at least look at the opposing point of view. You, on the other hand, make overblown, specious and umproven claims immediately without even considering the vast amount of evidence to the contrary.

    I didn’t make a mockery of you or your link, I merely said that the source of the study may be biased based on information on their site. Much like the Regnerus study, this study could be similarly tainted because of the preconceived views espoused by the site.

    Again, whether I “like” it or not is immaterial.

    Please try to stay on the topics that you originally raised (the veracity of which you failed to prove) and never justified with evidence from well-reviewed, scholarly journals. Now you’re throwing in nutrition and “big food.”. You’ve moved from the “animal research is useless” and “researchers make fortunes” both unproven by you, to big pharma, diabetes and your own anecdotal observations on that, to food and nutrition.

    ou’re moving into full-fledged science-denial now.

  16. John Ruff says:

    I bet people would lose weight just by not reading tabloid-esque articles like this one online, in a chair, sitting, for hours on a comment thread, eating junk food.

  17. Dave says:

    I’m referring only to diabetics ( my first sentence – I have type 2). Diabetic ketoacidosis can be fatal. I was not talking about the population in general. They can paleo diet all they want, but without enough insulin you get into trouble. Incidentally, some people have found out that they are diabetic by going into diabetic ketoacidosis.

  18. Drew2u says:

    I’m in a town that prides its self on the number of chain restaurants it has; if you count Applebee’s and Fudrucker’s as local.

  19. Monophylos Fortikos says:

    Go fuck yourself.

  20. Tatts says:

    I don’t buy it…”when you’re already feeling flabby and bad about yourself it’s that much more difficult”

    Who’s going to notice???
    36% of US adults are obese.
    69% of US adults are overweight (the figure includes obese)
    You’ll fit right in.

    It sounds like you’re making excuses.

  21. Tatts says:

    Okay. Question…
    Who wants a gut full of fermenting carbohydrates?
    What is the one guaranteed byproduct of fermentation?
    Do you work in an office where people can open windows reeeeeeally wide?

    This is so effing stupid.

    And one warning: Do NOT take this if you are also taking Alli !

  22. emjayay says:

    Mice are little bitty fast maturing fast reproducing mammals with similar systems to humans. They aren’t little bitty homo sapiens, but obviously they are used in millions of ways to investigate medical stuff that may apply to humans or other mammals.

  23. MyrddinWilt says:

    Depends on whether the humans eat the mice after the experiment or not.

  24. PaulWolfe says:

    [The researchers used mice in their experiments.]
    Is this article about mice or humans? If about the latter, then the research has no relevance. Surely the author knows that.

  25. 4th Turning says:

    You think those pumps come in a 13?

  26. Mike says:

    I’d like to suggest a novel approach that doesn’t involve torturing animals – eat healthier and exercise more. Studies on humans (which, incidentally, are the only studies applicable to humans) show that this works and creates a more healthy lifestyle, which leads to happier people (and happier mice).

  27. emjayay says:

    Hmmmmm, flowers. Sounds low calorie.

  28. emjayay says:

    I usually go with a diet soda in a frozen glass with a lot of ice, I know, so shoot me already.

  29. will says:

    Good for Katie Couric!

  30. 4th Turning says:

    This link is a transcript of the interview discussion. I have found
    drinking a big glass of water when all that growling starts calms things
    down a lot and is great for the bod in other ways, too.

  31. emjayay says:

    Nope. I saw at a glance that is was devoid of normal capitalization and decided to not bother taking the extra time to decipher it.

  32. emjayay says:

    It was short so I did. I often use some type of gentle humor in comments. And I rarely throw any stones if I don’t live in a glass house. Sorry you were not amused.
    The uses of normal capitalization and punctuation and grammar and spelling are simply practical things we have communally decided to use as a norm in order to facilitate comprehension. If one isn’t writing poetry I simply don’t understand not bothering with pressing the Shift key when typing the first letter of a sentence. It makes one’s writing much harder to read, although I suppose it makes the writer feel superior or something.

  33. emjayay says:

    No details on what drugs either, but I suspect a statin, a blood pressure drug like Enalpril, maybe a diuretic, and if the blood test showed low thyroid, synthroid. All things that would be typically prescribed after results from vitals, physical, and blood test but not related to the diabetes of unstated type.

  34. annatopia says:

    “tubbies”? that’s really rude.

    oh wait you won’t read this comment because it’s not capitalised.

  35. annatopia says:

    you can do it! i know it’s hard, been there done that, but you CAN if you have the will to change. you sound like you are motivated, so i absolutely wish you the best of luck.
    and believe me i hear you about the embarrassment. i do hot yoga and the first year of my practise i felt so intimidated by all the little skinny girls in the room. i felt like a whale, i wouldn’t even take my shirt off. but eventually my body really started changing and i became more comfortable in my own skin and more confident. i still remember the first day i practised with only shorty shorts and a sports bra. it was liberating.
    i believe you can do it. just get going… any movement will help… and of course i’m going to recommend hot yoga because it’s extremely low impact and has so many benefits physically and mentally… give it a try. it might change your life like it did mine. :)

  36. annatopia says:

    you obviously read it since you commented on it. and i don’t care for your grammar police. have a nice day.

  37. will says:

    Okay, Mr. Thoma, you can read these two articles if you want some facts about doctors being pill pimps. Or does Time Magazine share my bias as well?

  38. will says:

    Of course anything outside the medical establishment is a bias to someone who operates within that framework such as yourself. I would think that as a health care professional the study would peak your interest. Instead, your response is mockery. You may not like it, but people were helped and the results were documented. They reversed the disease. Given the fact that diabetes is an out of control epidemic, you would think more researchers would be looking into this approach. Of course, that would threaten not only the bottom line of the drug industry but also the food companies that want people to consume their nutritionally void, highly processed food.

  39. docsterx says:

    Again, your first paragraph is anecdotal and merely an opinion.

    And your evidence that the majority of doctors are “pill pimps” is? Did you ever consider that the “pills” might have kept tens of millions of people, like you, alive to be able to criticize pills and animal research studies? That prescription medicines do work?

    You just persist in making biased generalizations with little or no evicence.

  40. will says:

    The supplement companies are a rip off as well, I agree with you on that. What does work is a plant based diet of whole foods combined with regular exercise. It has worked for me and I have seen it work for other people as well.

    By the way, not all doctors are pill pimps, just the majority. People like John McDougall, Dean Ornish and Caldwell Esselstyn all have successful track records reversing disease through this approach. They get results. If I had listened to my doctor’s advice I would end up like my father who was on dozens of drugs by the time he had a fatal heart attack.

  41. docsterx says:

    It’s my understanding that not all high fat diets produce ketosis. It depende on the ratio of fats to other dietary components like protein and carbohydrate. The diet that these animals were fed may not have made them ketotic. See Table I in the cited article.

  42. docsterx says:

    “Anecdotal” means that that the information is based on unscientific reports from untrained observers. Additionally, the numbers in reports described as anecdotal are usually only a single patient or just a few patients. Far fewer than necessary to give validity to the statements presented. So, even if you have documents of your statements, they’re still anecdotal. As such, they may be interesting, but certainly not conclusive.

    You also mention that you were diagnosed with diabetes (not mentioning which type) and the doctor was going to place you on four medications. I’ve never heard of a newly diagnosed diabetic immediately being placed on four medications at once. Generally, one medication is started and the dose is titrated (if necessary) to the desired effect. Other medications may be added later if the initial medication is unsuccessful.

  43. 4th Turning says:

    “Some foods have significantly more Calories than others but what does the difference actually look like. Each of the photographs below represents 200 Calories of the particular type of food; the images are sorted from low to high calorie density. When you consider that an entire plate of broccoli contains the same number of Calories as a small spoonful of peanut butter, you might think twice the next time you decide what to eat. According to the U.S. Department of Agriculture, the average adult needs to consume about 2000 – 2500 Calories to maintain their weight. In other words, you have a fixed amount of Calories to “spend” each day; based on the following pictures, which would you eat?”

    There’re automatic grams-to-ounces calculators online for the mathematically challenged like myself.

  44. will says:

    I’m getting nostalgic for middle school with the “you started it.” Anyway, I don’t know what you mean by accusations but it is a really dumb argument to make the comparison between a lack of trust in our “health care” system and anti gay bigotry

  45. docsterx says:

    Yes. If you look at the author’s avatar and mine, you’ll note the resemblance.

    Of course big pharma will. Of course doctors are pill pimps. Of course you’re totally right. And of course you ignore the quack supplement companies making billions of dollars in profits/year off of the American public from bilking their gullible consumers. That’s your strategy, ignore the evidence and make unsubstantiated claims.

  46. docsterx says:

    Did you check out the provenance of that site? They may share your biases to a large degree.

  47. emjayay says:

    I have a knee jerk skepticism to any writing that does not include normal capitalization. So I don’t read it.

  48. emjayay says:

    How could this possibly work on the honor system? Is there someone who comes to your house with a certified scale? Didn’t think so.

  49. emjayay says:

    But tubbies can swim. Maybe drive to a pool in the next town where you don’t know anyone. Or live in NYC where no one knows anyone.

  50. emjayay says:

    Whatever works. The good thing about the Fast Diet, besides theoretical metabolic stuff, is that it’s not a day after day after day grind. The bad part is not being so hungry the day after the 600 calorie day you want to eat everything.

  51. GarySFBCN says:

    Hey, you started it with your accusations.

  52. Just_AC says:

    I came across a website a couple weeks that I am DEFINITELY considering joining. It is Basically, you make a bet that you can lose something like 4% of your weight in a month. Whoever succeeds splits the pot (minus the website commission) So, for me I weigh 200 and I would have to lose eight pounds and get down to 192.

    It sounds like it would give more motivation. Two weeks down the road and I’ve lost 4 lbs. “Chocolate milkshake? $200? Chocolate milkshake? $200? Sorry, Shake

  53. Will says:

    Now that’s just dumb.

  54. annatopia says:

    i must say, i’ve heard that so many times that i have a knee jerk skepticism towards anyone who says that it’s difficult to get into physical activity without losing weight first. there are many types of exercises that are low impact, such as walking and yoga… forgive me, but i truly see that as an excuse in most cases.
    if i’d had that attitude when i started getting healthy i never would’ve gotten where i am. and yea i know i’m making a blanket statement that doesn’t apply to everyone, and in some cases people can be so heavy that it’s hard to get started… but i truly believe anyone can start with simple activities. for example, even little things like parking your car as far away from the front door of whatever store you are going to… even adding 50-100 extra steps is a start you know?
    i don’t disagree with the point you’re making… it’s just the whole “i can’t start exercising until i lose weight” thing, it seems so counterintuitive to me.

  55. GarySFBCN says:

    While I think Will’s post makes him look to be a jerk, I know a few people who have kicked their diabetes through diet and exercise. Also, I’ve read that almost every diabetic who has bariatric surgery no longer has diabetes after the surgery. Doesn’t that fit-in with diet being a way to control/eliminate diabetes?

  56. GarySFBCN says:

    Due to an injury that impeded my physical activity for more than a year, I gained almost 30lbs. As I was overweight before, this extra weight pushed me into the ‘obese’ category.

    Now that I’m back to about 95% active (for about 3 months now), I’ve found that one day a week of walking for 5-7 hours (urban hikes), combined with a no-carb meal of protein and vegetables, I can lose 1-2lbs each week, and my metabolism improves – no hunger pangs and a higher metabolic rate.

    I recently heard about this 5-2 approach and it is close to what I’m doing, but only 6-1, and I eat more than 600 calories, but probably less than 1500.

  57. GarySFBCN says:

    Well if your doctor is bad, they all must be. Just like those damn gays.

  58. a1 says:

    What evidence do you have to support the statement: “fats break down into ketones and can be burned for fuel, but they don’t break down fully like carbs and will eventually cause problems with a lot of patients?”

    I know of no scientific or clinical evidence whatsoever that staying in dietary ketosis for long periods or even lifetimes causes problems for otherwise healthy people. None. Whereas there is lots of evidence that the modern high carb (HC) diet is unhealthy and even deadly for many people.

  59. emjayay says:

    While we’re off on losing weight instead of politics and gay issues, how about the Fast Diet – eating only 600 calories a day twice a week. Both words in the title make it sound like another fad and not what it is, but there is a lot of science behind it. Besides, it had a BBC documentary shown on PBS so it must be good.

  60. emjayay says:

    They should do an experiment with inulin combined with a diet of sugar creamed with butter.

  61. emjayay says:

    Isn’t there some actual real local pizza place you could call?

  62. Monophylos Fortikos says:

    It’s not the cliched villain of Big Pharma(TM) that stands to benefit if even the vaguest evidence is found for the usefulness of inulin; it’s the manufacturers of “dietary supplements” marketing their products to people who think that they don’t need real medicine, just powdered herbs in gelatin capsules.

  63. Mike_in_the_Tundra says:

    You are not differentiating between Type 1 and Type 2 diabetics.

  64. Monophylos Fortikos says:

    With me at least there’s a large measure of embarrassment at work. Taking regular exercise, even if it’s just walking, usually means going out in public, and when you’re already feeling flabby and bad about yourself it’s that much more difficult. Slimming down a little first, even by just a few pounds, goes a long way toward mitigating that.

    I’ve got an active job now (about the only thing I can get these days) so I’ve been maintaining my weight loss though I’d like to slim down even more.

  65. Dave says:

    Walking works. I was diagnosed with type 2 diabetes a little over a year ago. I weighed 350 pounds at the time. Shifting to a low carb diet worked out ofr me by an American Diabetes Association certified dietician and walking 4 times a week got me down to 290 within 5 months. I started at about three quarters of a mile at first. Within a month I was at 1.5 miles, and a few weeks later at 2 miles a day, 3 to 5 times a week. You burn more calories when you’re heavier – that’s simple physics. As for ultra low carb / paleo diets, they are not recommended – fats break down into ketones and can be burned for fuel, but they don’t break down fully like carbs and will eventually cause problems with a lot of patients. I’m 6’2″ and on a 2250 calorie a day diet, and if you read labels carefully and make some basic substitutions, it’s an easy diet to follow. Carbs spread out over the day, usually 3 meals and 3 snacks. My last A1C (which is a 3 month blood glucose average) was a 6. An A1C of 7 is what they want you to be at (down from the 9 or higher that most diabetics start at when they’re diagnosed).

  66. Drew2u says:

    I think of weight loss and fitness a kind of inverse snowball effect of each other. The larger a person it is, the more difficult it is to exercise. The more difficult it is to exercise, the more weight is loss due to exertion. The more weight is lost, the easier it is to exercise, the easier it is to exercise, the less weight is lost. Does that make a kind of weird sense?

  67. Drew2u says:

    I’m one of those people that getting into ketosis is fairly difficult, despite tracking very carefully and preparing 100% of my meals from scratch. It takes me about 3 weeks until I’m fully adapted, but by then there’s usually some kind of cultural appropriation of carb-rich foods that I’m obligated to take part in – whether it be a celebration of some kind or family/friends going out for dinner that one time in a very long time.
    I don’t think it’s terribly difficult to stay with, it’s just that my body takes a long time to become adapted and we live in a society where everything we look at is just the exact opposite. As it is, instead of cooking, tonight, my sister just wants to order Domino’s after a long road trip and we had a noodle casserole last night.

  68. will says:

    true that, damned missed an opportunity lol!

  69. Interesting. What about simply walking? I know it’s not supposed to be heart-friendly, as it’s not cardio, but I find just walking my dog once spring hits ends up losing me several pounds (though maybe it’s summer overall when I lose weight – but since I got the dog, I tend to lose more).

  70. Damn, I thought you were going to write “Mice are not men.” Would have been punnier :)

  71. will says:

    “You speak from very limited personal experience. Not from experience from studies done on large numbers of patients, not from working with diabetic patients or obese patients. You can’t generalize or make valid recommendations to others based on what you claim happened with you.”

    Here’s a study. It would be nice to get more studies like this that could lead to an actual diabetes cure but there are no non-human animals involved so that’s not likely to happen.

  72. will says:

    oh, also I have medical documentation to support everything in my comments.

  73. will says:

    Just for clarification, are you the author of the post? I can’t tell from your screen name whether or not you are Mr. Thoma or a reader.

    Anyway I was able to reign in a life threatening disease and I have the medical documentation to prove it. I asked my doctor if he wanted to read the book I was using as a guide but he was not interested. He said most people would not succeed, very dismissive of a person’s ability to rise to a challenge. And arrogant of course.

    Big Pharma will be involved in anything that makes money off of the obesity epidemic, it’s pretty naive to think otherwise. Doctors are pill pimps pretty much, at least in this country.

  74. Monophylos Fortikos says:

    In my experience, it’s difficult to get more physically active without losing some weight first. The resulting boost to confidence and energy makes it easier to get into more healthful habits like that.

  75. Monophylos Fortikos says:

    Time to eat lots of Jerusalem artichokes! (I rather like them.)

  76. docsterx says:

    One of the points here that you seem to have missed entirely, is that this in not a pharmaceutical. It’s not a drug or pill. It can be gotten entirely though dietary sources. So big pharma may not even be involved.

    No, wrong again, doctors often counsel overweight patients to exercise and manage their diets. Some send patients to nutritionists to help the patients manage weight problems. They may also recommend personal training, gym memberships, exercising regularly with friends or family. But many people would rather opt for a “pill.” Note the multi-billion dollar weight loss campaigns run, not by big pharma or doctors, but by scammers who promise quick weight loss.

    You speak from very limited personal experience. Not from experience from studies done on large numbers of patients, not from working with diabetic patients or obese patients. You can’t generalize or make valid recommendations to others based on what you claim happened with you.

    Your anecdotal case history is indeed amazing, virtually unbelievable.

  77. annatopia says:

    but HFLC diets are generally not sustainable in the long term. this is the adkins method, which kick starts ketosis and does produce fast results, but in almost all cases as soon as people return to eating a more balanced diet they begin to gain weight.
    in my opinion, this is another fad type diet that is only viable short term. the long term solution is to get off one’s butt, start exercising, and start cutting out the bad stuff (processed foods, sugars, etc). that’s really what works, but as you mention, so many people are addicted to bad foods and in many cases cannot motivate themselves to stick to an exercise plan. it took me decades to change those bad habits for good, so i get that it’s hard, but eventually we should be doing weight loss the right way (good foods + exercise) if we want to be sustain long term health.

  78. will says:

    No big surprise, more research needs to be done is always the case with these animal studies. Because mice are not people. The medical industry is focused on pills and instant gratification and it’s no wonder so many people are not able to stick to a diet that allows health to flourish, because doctors don’t push that approach very much. I speak from experience. When I discovered I was a diabetic, the doctor immediately wanted me on four different meds. I found a book on reversing diabetes through a low fat vegan diet and exercise. I took that approach against the advice of my doctor and was able to get my A1C levels to 6.5, down from 10.4 in a matter of weeks.

    Doctors should use their influence to benefit patients rather than the Pharmies.

  79. a1 says:

    A high-fat low carb (HFLC) diets cause formation of “ketone bodies” via ketosis (such as acetate), and doesn’t need Inulin to suppress appetite. HFLC diets lower appetite both through generating ketones and by stopping the sugar-insulin spike-hunger-more sugar merry-go-round that many are addicted to.

    As is is difficult for most people to break the sugar/flour addiction that is causing the epidemic of obesity in America to go to a more healthy HFLC diet, it is very doubtful that inulin would work to reduce appetite in this kind of diet. The sugar/flour addiction is much too powerful.

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