Mrs Clinton did not outline sanctions for countries that fail to reform same-sex laws, but an official memorandum directs US government agencies to consider gay rights when making aid and asylum decisions.
Her comments follows a warning by UK Prime Minister David Cameron last month that the UK would reduce some aid to countries that refuse to recognise gay rights.
Homosexual acts are illegal in most African countries, including key Western allies such as Uganda, Nigeria, Kenya, Egypt and Botswana.
Reacting angrily to Mrs Clinton’s speech, Ugandan presidential adviser John Nagenda told the BBC: “That fellow [Mr Cameron] said the same thing. Now this woman [Clinton] is interfering.
“If the Americans think the can tell us what to do, they can go to hell.”
Well, Uganda gets military assistance from the US. They can go to hell.